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Different definition / meanings for the word "Cialis":

A medication used to treat erectile dysfunction that works by increasing the flow of blood into the penis.

Tadalafil: virility drug (trade name Cialis) used to treat erectile dysfunction in men.

Cialis® (generic name, tadalafil) is the brand name of a drug used to treat male erectile dysfunction (impotence), developed by the biotech firm ICOS and marketed worldwide by Eli Lilly. Cialis has FDA approval and appeared in U.S. stores in December, 2003. It works by inhibiting an enzyme known as PDE5. Due to its 36-hour effect it is also known as Weekend Pill.

Cialis drug history

The history of Cialis cannot be discussed without mentioning Pfizer's drug, Viagra. The FDA's approval on March 27, 1998, led this prescription drug, Viagra, to a ground breaking success in just the first year of introduction as Pfizer sold drugs worth over a billion dollars. However, things changed considerably for the giant of erectile dysfunction drugs when the FDA also approved Levitra in August 19, 2003, and Cialis in November 21, 2003. In 1993 the drug company Icos began studying IC351, which is a PDE5 enzyme inhibitor, and this is basically the process through which the erectile dysfunction drugs work. In 1994, Pfizer scientists discovered that Sildenafil Citrate, which is a white crystalline powder that temporarily normalizes erectile function of the penis by blocking an enzyme known to inhibit the production of a chemical that causes erections, caused the heart patients that were participating in a clinical study of a heart medicine to have erections. Although the scientists were not testing the chemical compound IC351 for erectile dysfunction, the compound seemed to have a side effect which could potentially be worth millions, if not billions of dollars. Soon Icos received its very first patent in 1994 on IC351, and the clinical trials of phase I took place in 1995. In 1997, phase II clinical studies began and Icos performed its first study on patients with erectile dysfunction. Phase II lasted about two years, and after that phase III began.

In 1998, ICOS Corporation, and Eli Lilly and Company, commercialized the drug for erectile dysfunction, and two years later they filed a new drug application with the U.S. Food and Drug Administration for IC351; the only difference was that this time they decided to call the drug, Cialis. In May of 2002, Icos and Eli Lilly and Company reported to the American Urological Association that the phase III tests show that Cialis works for up to 36 hours, and one year later Icos and Eli Lilly and Company received the U.S. FDA's approval for Cialis. One advantage that Cialis has over Viagra is that tadalafil has an half-life of 17.5 hours (and thus Cialis is advertised to work for up to 36 hours) as compared to 4 hours half-life for sildenafil (Viagra).

Eli Lilly purchased ICOS corporation for $2.1 billion dollars in 2006.

How Does Cialis Work?
An erection occurs when blood vessels in the penis expand in response to sexual stimulation, allowing increased blood flow into the penile tissue. The body produces an enzyme (PDE5) thatstops this process. Cialis aids a man's natural ability to get and sustain an erection by blocking that
enzyme, thus allowing increased blood flow to the penis in response to sexual stimulation. Cialis will only help a man to get an erection if he is sexually stimulated.

Who is Cialis For?
Cialis is indicated for men with ED.
In clinical trials, Cialis improved erectile function in patients with ED, including difficult to treat patients, like men who have diabetes and those who developed ED after prostate cancer surgery.

What is the Safety Profile of Cialis?
In clinical trials, the most common side effects with Cialis were headache, upset stomach, backache, and muscle ache. Most men weren’t bothered by the side effects enough to stop taking Cialis. In placebo controlled Phase III clinical trials, discontinuation rates in patients treated with Cialis 10 mg or 20 mg was 3.1%, compared to 1.4% in placebo treated patients.
Men who experience an erection for more than four hours should seek immediate medical attention.
Cialis does not protect a man or his partner from sexually transmitted diseases, including HIV.
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